Fig 1: RUNDC3A affects GNEC proliferation by regulating SNAP25 expression.A Effect of RUNDC3A knockdown in GNEC cell lines. B The changes in GNEC cell proliferation after RUNDC3A knockdown. C–E The growth rate of GNEC cells in a xenograft model after RUNDC3A knockdown. F, G The Ki-67 expression level in SNAP25- and RUNDC3A-knockdown xenograft models. H The correlation of SNAP25 and RUNDC3A expression in GNEC and GAC patient samples. I The correlation of SNAP25 and RUNDC3A expression in SCLC and LUAD patient samples. J The correlation of SNAP25 and RUNDC3A expression in PNET and PAC patient samples. K The correlation of SNAP25 and RUNDC3A expression in SINEC patient samples. L–N SNAP25 expression was mediated by RUNDC3A expression in GNEC cells. O The correlation of SNAP25 and RUNDC3A expression in the RUNDC3A-knockdown xenograft model. P The SNAP25-mediated proliferation rate decrease could be rescued by RUNDC3A overexpression in GNEC cells. Plots indicate the average ± s.d. Significance test is indicated *(p < 0.05).